Vinblastine is used to treat Hodgkin's disease, certain types of lymphoma, testicular cancer, breast cancer, choriocarcinoma (a type of uterine cancer), Kaposi's sarcoma, and Letterer-Siwe disease. Vinblastine is often used in combination with other cancer medications
Vinblastine works by stopping the cancer cells from separating into 2 new cells. So it blocks the growth of the cancer.
Vinblastine belongs to a class of chemotherapy drugs called alkaloids. The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The plant alkaloids are cell-cycle specific. This means they attack the cells during various phases of division.
Among the Vinca alkaloids, peripheral neuropathy is the principal toxicity of Vincristine and neutropenia of Vinblastine, Vinorelbine, and Vindesine. Vinblastine neuropathy is rare and mild; whereas, Vinorelbine and Vindesine can be associated with moderate neuropathy.
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Vinblastine sulfate is a cytotoxic drug that arrests cell growth at the metaphase. Its actions are more pronounced on the rapidly dividing cell than on the normal cell.
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Vinblastine use, safety information, warnings and side effects, indications and usage, adverse reactions and clinical pharmacology.
This section displays common question about the Vinblastine Solution for Injection.
Caution – This preparation should be administered by individuals experienced in the administration of vinblastine sulfate (vinblastine sulfate injection) . It is extremely important that the intravenous needle or catheter be properly positioned before any vinblastine sulfate (vinblastine sulfate injection) is injected. Leakage into surrounding tissue during intravenous administration of vinblastine sulfate (vinblastine sulfate injection) may cause considerable irritation. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis.
FATAL IF GIVEN INTRATHECALLY. FOR INTRAVENOUS USE ONLY.
See WARNINGS for the treatment of patients given intrathecal vinblastine.
