vinblastine sulfate 1mg ml solution for injection - Taj pharma

Vinblastine Sulfate
1mg/ml Solution

Vinblastine sulfate is the salt of an alkaloid extracted from Vincarosea Linn., a common flowering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB. It is a stathmokinetic oncolytic agent. When treated in vitro with this preparation, growing cells are arrested in metaphase.

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Taj Pharma is one of the largest generic pharmaceutical company in India. We hold top positions in different established markets worldwide and are building a strong presence in many emerging generics markets. You can contact Taj Pharma India's business by telephone on 91 022-2637-4592, if you have an enquiry about the company, our healthcare business, or one of our medicines.

Product Summary

Vinblastine sulfate is a cytotoxic drug that arrests cell growth at the metaphase. Its actions are more pronounced on the rapidly dividing cell than on the normal cell.

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Patient Care

Vinblastine use, safety information, warnings and side effects, indications and usage, adverse reactions and clinical pharmacology.

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Drug Description

Vinblastine Solution for Injection

Vinblastine Sulfate for Injection USP is vincaleukoblastine, sulfate (1:1) (salt). It is the salt of an alkaloid extracted from Vinca rosea Linn., a common flowering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB. It is a stathmokinetic oncolytic agent. When treated in vitro with this preparation, growing cells are arrested in metaphase.

Chemical and physical evidence indicates that vinblastine sulfate (vinblastine sulfate injection) has the molecular formula C46H58O9N4•H2SO4 and that it is a dimeric alkaloid containing both indole and dihydroindole moieties.

The structural formula is as follows:

vinblastine sulfate 1mg ml solution for injection - Taj pharma

M.W.= 909.07

Vinblastine sulfate (vinblastine sulfate injection) is a white to off-white powder. It is freely soluble in water, soluble in methanol, and slightly soluble in ethanol. It is insoluble in benzene, ether, and naphtha.

The clinical formulation is supplied in a sterile form for intravenous use only. Vials of Vinblastine Sulfate for Injection USP (vinblastine sulfate (vinblastine sulfate injection) injection) contain 10 mg (0.011 mmol) of vinblastine sulfate (vinblastine sulfate injection) , in the form of a white, amorphous, solid lyophilized plug, without excipients. After reconstitution with sodium chloride solution, the pH of the resulting solution lies in the range of 3.5 to 5.

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Important Safety Information

Caution – This preparation should be administered by individuals experienced in the administration of vinblastine sulfate (vinblastine sulfate injection) . It is extremely important that the intravenous needle or catheter be properly positioned before any vinblastine sulfate (vinblastine sulfate injection) is injected. Leakage into surrounding tissue during intravenous administration of vinblastine sulfate (vinblastine sulfate injection) may cause considerable irritation. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis.

FATAL IF GIVEN INTRATHECALLY. FOR INTRAVENOUS USE ONLY.

See WARNINGS for the treatment of patients given intrathecal vinblastine.

Storage

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: seizures.

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Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. Keep all your medical/lab appointments. If you miss a dose, contact your doctor to establish a new dosing schedule.

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