The stage in the cell cycle (the sequence of events in the life of a cell) when a chromosome is most highly condensed (and stains most darkly in the laboratory) and so is easiest to distinguish and to study.
Metaphase chromosomes are therefore often chosen for karyotyping and for chromosome analysis because they are readily seen. However, chromosomes in metaphase can be so condensed and scrunched up that it is difficult to make out much in the way of detail. More distended chromosomes (in prometaphase or prophase) are sometimes selected for study when fine details are important.
The term "metaphase " was introduced by Strasburger in 1884 to denote the stage in nuclear division after (in Greek: meta) the time when he mistakenly thought chromosomes had just divided into chromatids. It was later realized that chromosomes are already double when nuclear division begins. However, the term "metaphase" has stuck.
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Vinblastine sulfate is a cytotoxic drug that arrests cell growth at the metaphase. Its actions are more pronounced on the rapidly dividing cell than on the normal cell.
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Vinblastine use, safety information, warnings and side effects, indications and usage, adverse reactions and clinical pharmacology.
This section displays common question about the Vinblastine Solution for Injection.
Caution – This preparation should be administered by individuals experienced in the administration of vinblastine sulfate (vinblastine sulfate injection) . It is extremely important that the intravenous needle or catheter be properly positioned before any vinblastine sulfate (vinblastine sulfate injection) is injected. Leakage into surrounding tissue during intravenous administration of vinblastine sulfate (vinblastine sulfate injection) may cause considerable irritation. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis.
FATAL IF GIVEN INTRATHECALLY. FOR INTRAVENOUS USE ONLY.
See WARNINGS for the treatment of patients given intrathecal vinblastine.
